Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans

Glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells is potentiated by cAMP-elevating agents, such as the incretin hormone glucagon-like peptide-1 (GLP-1) and cAMP exerts its insulin secretagogue action by activating both protein kinase A (PKA) and the cAMP-regulated guanine nucleotid...

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Hlavní autoři: Dzhura, Igor, Chepurny, Oleg G, Leech, Colin A, Roe, Michael W, Dzhura, Elvira, Xu, Xin, Lu, Youming, Schwede, Frank, Genieser, Hans-G, Smrcka, Alan V, Holz, George G
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116928/
https://ncbi.nlm.nih.gov/pubmed/21478675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/isl.3.3.15507
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