Caveolin-1 negatively regulates a metalloprotease-dependent epidermal growth factor receptor transactivation by angiotensin II

A metalloprotease, ADAM17, mediates the generation of mature ligands for the epidermal growth factor receptor (EGFR). This is the key signaling step by which angiotensin II (AngII) induces EGFR transactivation leading to hypertrophy and migration of vascular smooth muscle cells (VSMCs). However, the...

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Autores principales: Takaguri, Akira, Shirai, Heigoro, Kimura, Keita, Hinoki, Akinari, Eguchi, Kunie, Carlile-Klusacek, MaryEllen, Yang, Baohua, Rizzo, Victor, Eguchi, Satoru
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035769/
https://ncbi.nlm.nih.gov/pubmed/21172357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.12.009
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