Aberrantly Glycosylated IgA1 as a Factor in the Pathogenesis of IgA Nephropathy

Predominant or codominant immunoglobulin (Ig) A deposition in the glomerular mesangium characterizes IgA nephropathy (IgAN). Accumulated glomerular IgA is limited to the IgA1 subclass and usually galactose-deficient. This underglycosylated IgA may play an important role in the pathogenesis of IgAN....

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Hlavní autoři: Tanaka, Mototsugu, Seki, George, Someya, Tomonosuke, Nagata, Michio, Fujita, Toshiro
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2011
Témata:
Review Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034910/
https://ncbi.nlm.nih.gov/pubmed/21318178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/470803
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