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Archaeosome Adjuvant Overcomes Tolerance to Tumor-Associated Melanoma Antigens Inducing Protective CD8(+) T Cell Responses

Vesicles comprised of the ether glycerolipids of the archaeon Methanobrevibacter smithii (archaeosomes) are potent adjuvants for evoking CD8(+) T cell responses. We therefore explored the ability of archaeosomes to overcome immunologic tolerance to self-antigens. Priming and boosting of mice with ar...

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Autori principali: Krishnan, Lakshmi, Deschatelets, Lise, Stark, Felicity C., Gurnani, Komal, Sprott, G. Dennis
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi Publishing Corporation 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034908/
https://ncbi.nlm.nih.gov/pubmed/21318177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2010/578432
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