Smac mimetic-derived augmentation of chemotherapeutic response in experimental pancreatic cancer

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is highly resistant to conventional chemotherapy, in part due to the overexpression of inhibitors of apoptosis proteins (IAPs). Smac is an endogenous IAP-antagonist, which renders synthetic Smac mimetics attractive anticancer agents. We evaluated t...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Awasthi, Niranjan, Kirane, Amanda, Schwarz, Margaret A, Toombs, Jason E, Brekken, Rolf A, Schwarz, Roderich E
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: BioMed Central 2011
विषय:
Research Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034706/
https://ncbi.nlm.nih.gov/pubmed/21226944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-11-15
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