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Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli
Taxol (paclitaxel) is a potent anticancer drug first isolated from the Taxus brevifolia Pacific yew tree. Currently, cost-efficient production of Taxol and its analogs remains limited. Here, we report a multivariate-modular approach to metabolic-pathway engineering that succeeded in increasing titer...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2010
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3034138/ https://ncbi.nlm.nih.gov/pubmed/20929806 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1191652 |
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