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Metabolite Profiling Identified Methylerythritol Cyclodiphosphate Efflux as a Limiting Step in Microbial Isoprenoid Production

Isoprenoids are natural products that are all derived from isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). These precursors are synthesized either by the mevalonate (MVA) pathway or the 1-Deoxy-D-Xylulose 5-Phosphate (DXP) pathway. Metabolic engineering of microbes has enabled o...

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Detalhes bibliográficos
Main Authors: Zhou, Kang, Zou, Ruiyang, Stephanopoulos, Gregory, Too, Heng-Phon
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487848/
https://ncbi.nlm.nih.gov/pubmed/23133596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047513
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