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Metabolite Profiling Identified Methylerythritol Cyclodiphosphate Efflux as a Limiting Step in Microbial Isoprenoid Production

Isoprenoids are natural products that are all derived from isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). These precursors are synthesized either by the mevalonate (MVA) pathway or the 1-Deoxy-D-Xylulose 5-Phosphate (DXP) pathway. Metabolic engineering of microbes has enabled o...

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Autores principales: Zhou, Kang, Zou, Ruiyang, Stephanopoulos, Gregory, Too, Heng-Phon
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487848/
https://ncbi.nlm.nih.gov/pubmed/23133596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047513
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