Development and validation of a high-performance liquid chromatography/tandem mass spectrometry method for the determination of artemether and its active metabolite dihydroartemisinin in human plasma

To study the pharmacokinetic profile of artemether in children and in the context of antiviral drugs for HIV infected patients co-infected with malaria, an LC-MS/MS method was developed and validated to simultaneously determine artemether and its metabolite dihydroartemisinin in human plasma. Using...

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Hauptverfasser: Huang, Liusheng, Jayewardene, Anura L., Li, Xiaohua, Marzan, Florence, Lizak, Patricia S., Aweeka, Francesca T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034030/
https://ncbi.nlm.nih.gov/pubmed/19646837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2009.06.051
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