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Development and validation of a hydrophilic interaction liquid chromatography-tandem mass spectrometry method for determination of isoniazid in human plasma

An LC-MS/MS method for the determination of isoniazid in human plasma was developed and validated. Human plasma aliquots of 100 μL were used for analysis. The assay used nialamide as the internal standard. The calibration curve concentration range was 50 to 10,000 ng/mL. Sample preparation utilized...

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Detalhes bibliográficos
Main Authors: Huang, Liusheng, Marzan, Florence, Jayewardene, Anura L., Lizak, Patricia S., Li, Xiaohua, Aweeka, Francesca T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3032609/
https://ncbi.nlm.nih.gov/pubmed/19112051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2008.12.024
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