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Varenicline blocks nicotine intake in rats with extended access to nicotine self-administration

RATIONALE: Much evidence indicates that individuals use tobacco primarily to experience the psychopharmacological properties of nicotine. Varenicline, a partial α4β2 nicotinic acetylcholine receptor (nAChR) agonist, is effective in reducing nicotine craving and relapse in smokers, suggesting that α4...

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Detalhes bibliográficos
Main Authors: George, Olivier, Lloyd, Allison, Carroll, F. Ivy, Damaj, M. Imad, Koob, George F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033995/
https://ncbi.nlm.nih.gov/pubmed/20924754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-010-2024-3
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