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A Novel Pentamethoxyflavone Down-Regulates Tumor Cell Survival and Proliferative and Angiogenic Gene Products through Inhibition of IκB Kinase Activation and Sensitizes Tumor Cells to Apoptosis by Cytokines and Chemotherapeutic Agents

Most anticancer drugs have their origin in traditional medicinal plants. We describe here a flavone, 5,3′-dihydroxy-3,6,7,8,4′-pentamethoxyflavone (PMF), from the leaves of the Thai plant Gardenia obtusifolia, that has anti-inflammatory and anticancer potential. Because the nuclear factor-κB (NF-κB)...

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Detaylı Bibliyografya
Asıl Yazarlar: Phromnoi, Kanokkarn, Reuter, Simone, Sung, Bokyung, Prasad, Sahdeo, Kannappan, Ramaswamy, Yadav, Vivek R., Chanmahasathien, Wisinee, Limtrakul, Pornngarm, Aggarwal, Bharat B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Pharmacology and Experimental Therapeutics 2011
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033709/
https://ncbi.nlm.nih.gov/pubmed/20930110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.067512
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