A Novel Pentamethoxyflavone Down-Regulates Tumor Cell Survival and Proliferative and Angiogenic Gene Products through Inhibition of IκB Kinase Activation and Sensitizes Tumor Cells to Apoptosis by Cytokines and Chemotherapeutic Agents

Most anticancer drugs have their origin in traditional medicinal plants. We describe here a flavone, 5,3′-dihydroxy-3,6,7,8,4′-pentamethoxyflavone (PMF), from the leaves of the Thai plant Gardenia obtusifolia, that has anti-inflammatory and anticancer potential. Because the nuclear factor-κB (NF-κB)...

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Main Authors: Phromnoi, Kanokkarn, Reuter, Simone, Sung, Bokyung, Prasad, Sahdeo, Kannappan, Ramaswamy, Yadav, Vivek R., Chanmahasathien, Wisinee, Limtrakul, Pornngarm, Aggarwal, Bharat B.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033709/
https://ncbi.nlm.nih.gov/pubmed/20930110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.067512
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