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Modification of Cysteine 179 of IκBα Kinase by Nimbolide Leads to Down-regulation of NF-κB-regulated Cell Survival and Proliferative Proteins and Sensitization of Tumor Cells to Chemotherapeutic Agents

Reverse pharmacology, also called the “bedside to bench” approach, that deals with new uses for a well known molecular entity has been used extensively in cancer drug development to identify novel compounds and delineate their mechanisms of action. Here, we show that nimbolide, a triterpenoid isolat...

সম্পূর্ণ বিবরণ

সংরক্ষণ করুন:
গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক: Gupta, Subash C., Prasad, Sahdeo, Reuter, Simone, Kannappan, Ramaswamy, Yadav, Vivek R., Ravindran, Jayaraj, Hema, Padmanabhan S., Chaturvedi, Madan M., Nair, Mangalam, Aggarwal, Bharat B.
বিন্যাস: Artigo
ভাষা:Inglês
প্রকাশিত: American Society for Biochemistry and Molecular Biology 2010
বিষয়গুলি:
অনলাইন ব্যবহার করুন:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975164/
https://ncbi.nlm.nih.gov/pubmed/20829362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.161984
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