Modification of Cysteine 179 of IκBα Kinase by Nimbolide Leads to Down-regulation of NF-κB-regulated Cell Survival and Proliferative Proteins and Sensitization of Tumor Cells to Chemotherapeutic Agents

Reverse pharmacology, also called the “bedside to bench” approach, that deals with new uses for a well known molecular entity has been used extensively in cancer drug development to identify novel compounds and delineate their mechanisms of action. Here, we show that nimbolide, a triterpenoid isolat...

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Bibliographic Details
Main Authors: Gupta, Subash C., Prasad, Sahdeo, Reuter, Simone, Kannappan, Ramaswamy, Yadav, Vivek R., Ravindran, Jayaraj, Hema, Padmanabhan S., Chaturvedi, Madan M., Nair, Mangalam, Aggarwal, Bharat B.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975164/
https://ncbi.nlm.nih.gov/pubmed/20829362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.161984
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