Modification of Cysteine 179 of IκBα Kinase by Nimbolide Leads to Down-regulation of NF-κB-regulated Cell Survival and Proliferative Proteins and Sensitization of Tumor Cells to Chemotherapeutic Agents

Reverse pharmacology, also called the “bedside to bench” approach, that deals with new uses for a well known molecular entity has been used extensively in cancer drug development to identify novel compounds and delineate their mechanisms of action. Here, we show that nimbolide, a triterpenoid isolat...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Gupta, Subash C., Prasad, Sahdeo, Reuter, Simone, Kannappan, Ramaswamy, Yadav, Vivek R., Ravindran, Jayaraj, Hema, Padmanabhan S., Chaturvedi, Madan M., Nair, Mangalam, Aggarwal, Bharat B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975164/
https://ncbi.nlm.nih.gov/pubmed/20829362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.161984
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge