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Nimbolide Sensitizes Human Colon Cancer Cells to TRAIL through Reactive Oxygen Species- and ERK-dependent Up-regulation of Death Receptors, p53, and Bax

TNF-related apoptosis-inducing ligand (TRAIL) shows promise as a cancer treatment, but acquired tumor resistance to TRAIL is a roadblock. Here we investigated whether nimbolide, a limonoid, could sensitize human colon cancer cells to TRAIL. As indicated by assays that measure esterase activity, sub-...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Gupta, Subash C., Reuter, Simone, Phromnoi, Kanokkarn, Park, Byoungduck, Hema, Padmanabhan S., Nair, Mangalam, Aggarwal, Bharat B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020720/
https://ncbi.nlm.nih.gov/pubmed/21078664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.191379
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