Caricamento...

Nimbolide Sensitizes Human Colon Cancer Cells to TRAIL through Reactive Oxygen Species- and ERK-dependent Up-regulation of Death Receptors, p53, and Bax

TNF-related apoptosis-inducing ligand (TRAIL) shows promise as a cancer treatment, but acquired tumor resistance to TRAIL is a roadblock. Here we investigated whether nimbolide, a limonoid, could sensitize human colon cancer cells to TRAIL. As indicated by assays that measure esterase activity, sub-...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Gupta, Subash C., Reuter, Simone, Phromnoi, Kanokkarn, Park, Byoungduck, Hema, Padmanabhan S., Nair, Mangalam, Aggarwal, Bharat B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020720/
https://ncbi.nlm.nih.gov/pubmed/21078664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.191379
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !