Cargando...

Nimbolide Sensitizes Human Colon Cancer Cells to TRAIL through Reactive Oxygen Species- and ERK-dependent Up-regulation of Death Receptors, p53, and Bax

TNF-related apoptosis-inducing ligand (TRAIL) shows promise as a cancer treatment, but acquired tumor resistance to TRAIL is a roadblock. Here we investigated whether nimbolide, a limonoid, could sensitize human colon cancer cells to TRAIL. As indicated by assays that measure esterase activity, sub-...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Gupta, Subash C., Reuter, Simone, Phromnoi, Kanokkarn, Park, Byoungduck, Hema, Padmanabhan S., Nair, Mangalam, Aggarwal, Bharat B.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020720/
https://ncbi.nlm.nih.gov/pubmed/21078664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.191379
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!