Azadirone, a Limonoid Tetranortriterpene, Induces Death Receptors and Sensitizes Human Cancer Cells to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) through a p53 Protein-independent Mechanism: EVIDENCE FOR THE ROLE OF THE ROS-ERK-CHOP-DEATH RECEPTOR PATHWAY

Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has shown efficacy in a phase 2 clinical trial, development of resistance to TRAIL by tumor cells is a major roadblock. We investigated whether azadirone, a limonoidal tetranortriterpene, can sensitize human tumor cells to TRAI...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Gupta, Subash C., Francis, Sajin K., Nair, Mangalam S., Mo, Yin-Yuan, Aggarwal, Bharat B.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Biochemistry and Molecular Biology 2013
الموضوعات:
Signal Transduction
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820870/
https://ncbi.nlm.nih.gov/pubmed/24078627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.455188
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