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Gossypol Induces Death Receptor-5 through Activation of the ROS-ERK-CHOP Pathway and Sensitizes Colon Cancer Cells to TRAIL

Development of resistance to TRAIL, an apoptosis-inducing cytokine, is one of the major problems in its development for cancer treatment. Thus, pharmacological agents that are safe and can sensitize the tumor cells to TRAIL are urgently needed. We investigated whether gossypol, a BH3 mimetic that is...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Sung, Bokyung, Ravindran, Jayaraj, Prasad, Sahdeo, Pandey, Manoj K., Aggarwal, Bharat B.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2010
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975165/
https://ncbi.nlm.nih.gov/pubmed/20837473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.172767
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