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Gossypol Induces Death Receptor-5 through Activation of the ROS-ERK-CHOP Pathway and Sensitizes Colon Cancer Cells to TRAIL

Development of resistance to TRAIL, an apoptosis-inducing cytokine, is one of the major problems in its development for cancer treatment. Thus, pharmacological agents that are safe and can sensitize the tumor cells to TRAIL are urgently needed. We investigated whether gossypol, a BH3 mimetic that is...

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Библиографические подробности
Главные авторы: Sung, Bokyung, Ravindran, Jayaraj, Prasad, Sahdeo, Pandey, Manoj K., Aggarwal, Bharat B.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975165/
https://ncbi.nlm.nih.gov/pubmed/20837473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.172767
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