Design, Preparation, and Characterization of High-Activity Mutants of Human Butyrylcholinesterase Specific for Detoxification of Cocaine

Cocaine is a widely abused drug without a U.S. Food and Drug Administration-approved medication. There is a recognized, promising anticocaine medication to accelerate cocaine metabolism, producing biologically inactive metabolites via a route similar to the primary cocaine-metabolizing pathway [i.e....

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Main Authors: Xue, Liu, Ko, Mei-Chuan, Tong, Min, Yang, Wenchao, Hou, Shurong, Fang, Lei, Liu, Junjun, Zheng, Fang, Woods, James H., Tai, Hsin-Hsiung, Zhan, Chang-Guo
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033707/
https://ncbi.nlm.nih.gov/pubmed/20971807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.068494
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