A Novel Notch Protein, N2N, Targeted by Neutrophil Elastase and Implicated in Hereditary Neutropenia

Mutations in ELA2, encoding the human serine protease neutrophil elastase, cause cyclic and severe congenital neutropenia, and recent evidence indicates that the mutations alter the membrane trafficking of neutrophil elastase. These disorders feature impaired bone marrow production of neutrophils al...

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Bibliographische Detailangaben
Hauptverfasser: Duan, Zhijun, Li, Feng-Qian, Wechsler, Jeremy, Meade-White, Kimberly, Williams, Kayleen, Benson, Kathleen F., Horwitz, Marshall
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Cell Growth and Development
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC303357/
https://ncbi.nlm.nih.gov/pubmed/14673143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.1.58-70.2004
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