A Novel Notch Protein, N2N, Targeted by Neutrophil Elastase and Implicated in Hereditary Neutropenia

Mutations in ELA2, encoding the human serine protease neutrophil elastase, cause cyclic and severe congenital neutropenia, and recent evidence indicates that the mutations alter the membrane trafficking of neutrophil elastase. These disorders feature impaired bone marrow production of neutrophils al...

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Detalhes bibliográficos
Main Authors: Duan, Zhijun, Li, Feng-Qian, Wechsler, Jeremy, Meade-White, Kimberly, Williams, Kayleen, Benson, Kathleen F., Horwitz, Marshall
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC303357/
https://ncbi.nlm.nih.gov/pubmed/14673143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.1.58-70.2004
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