Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells

Although practiced clinically for over 40 years, the use of hematopoietic stem cell (HSC) transplants remains limited by the ability to expand these cells ex vivo. An unbiased screen with primary human HSC identified a purine derivative, StemRegenin 1 (SR1), that promotes the ex vivo expansion of CD...

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Autores principales: Boitano, Anthony E., Wang, Jian, Romeo, Russell, Bouchez, Laure C., Parker, Albert E., Sutton, Sue E., Walker, John R., Flaveny, Colin A., Perdew, Gary H., Denison, Michael S., Schultz, Peter G., Cooke, Michael P.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033342/
https://ncbi.nlm.nih.gov/pubmed/20688981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1191536
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