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Ligand Promiscuity of Aryl Hydrocarbon Receptor Agonists and Antagonists Revealed by Site-Directed Mutagenesis

The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that can be activated by structurally diverse chemicals. To examine the mechanisms responsible for the promiscuity in AhR ligand binding, we determined the effects of mutations within the AhR ligand-binding domain (LBD) o...

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Bibliographische Detailangaben
Hauptverfasser: Soshilov, Anatoly A., Denison, Michael S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993610/
https://ncbi.nlm.nih.gov/pubmed/24591650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01183-13
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