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Ligand Promiscuity of Aryl Hydrocarbon Receptor Agonists and Antagonists Revealed by Site-Directed Mutagenesis

The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that can be activated by structurally diverse chemicals. To examine the mechanisms responsible for the promiscuity in AhR ligand binding, we determined the effects of mutations within the AhR ligand-binding domain (LBD) o...

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書誌詳細
主要な著者: Soshilov, Anatoly A., Denison, Michael S.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993610/
https://ncbi.nlm.nih.gov/pubmed/24591650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01183-13
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