Trinitrophenyl derivatives bind differently from parent adenine nucleotides to Ca(2+)-ATPase in the absence of Ca(2+)

Trinitrophenyl derivatives of adenine nucleotides are widely used for probing ATP-binding sites. Here we describe crystal structures of Ca(2+)-ATPase, a representative P-type ATPase, in the absence of Ca(2+) with bound ATP, trinitrophenyl-ATP, -ADP, and -AMP at better than 2.4-Å resolution, stabiliz...

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Bibliographic Details
Main Authors: Toyoshima, Chikashi, Yonekura, Shin-Ichiro, Tsueda, Junko, Iwasawa, Shiho
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033254/
https://ncbi.nlm.nih.gov/pubmed/21239683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1017659108
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