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What ATP binding does to the Ca(2+) pump and how nonproductive phosphoryl transfer is prevented in the absence of Ca(2+)
Under physiological conditions, most Ca(2+)-ATPase (SERCA) molecules bind ATP before binding the Ca(2+) transported. SERCA has a high affinity for ATP even in the absence of Ca(2+), and ATP accelerates Ca(2+) binding at pH values lower than 7, where SERCA is in the E2 state with low-affinity Ca(2+)-...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7414164/ https://ncbi.nlm.nih.gov/pubmed/32675243 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2006027117 |
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