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What ATP binding does to the Ca(2+) pump and how nonproductive phosphoryl transfer is prevented in the absence of Ca(2+)

Under physiological conditions, most Ca(2+)-ATPase (SERCA) molecules bind ATP before binding the Ca(2+) transported. SERCA has a high affinity for ATP even in the absence of Ca(2+), and ATP accelerates Ca(2+) binding at pH values lower than 7, where SERCA is in the E2 state with low-affinity Ca(2+)-...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Kabashima, Yoshiki, Ogawa, Haruo, Nakajima, Rie, Toyoshima, Chikashi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2020
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7414164/
https://ncbi.nlm.nih.gov/pubmed/32675243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2006027117
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