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Mechanism of the E2 to E1 transition in Ca(2+) pump revealed by crystal structures of gating residue mutants
Ca(2+)-ATPase of sarcoplasmic reticulum (SERCA1a) pumps two Ca(2+) per ATP hydrolyzed from the cytoplasm and two or three protons in the opposite direction. In the E2 state, after transferring Ca(2+) into the lumen of sarcoplasmic reticulum, all of the acidic residues that coordinate Ca(2+) are thou...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6294896/ https://ncbi.nlm.nih.gov/pubmed/30482857 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1815472115 |
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