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Mechanism of the E2 to E1 transition in Ca(2+) pump revealed by crystal structures of gating residue mutants

Ca(2+)-ATPase of sarcoplasmic reticulum (SERCA1a) pumps two Ca(2+) per ATP hydrolyzed from the cytoplasm and two or three protons in the opposite direction. In the E2 state, after transferring Ca(2+) into the lumen of sarcoplasmic reticulum, all of the acidic residues that coordinate Ca(2+) are thou...

詳細記述

保存先:
書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Tsunekawa, Naoki, Ogawa, Haruo, Tsueda, Junko, Akiba, Toshihiko, Toyoshima, Chikashi
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294896/
https://ncbi.nlm.nih.gov/pubmed/30482857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1815472115
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