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Unique Dynamic Properties of DNA Duplexes Containing Interstrand Crosslinks

Bifunctional DNA alkylating agents form a diverse assortment of covalent DNA interstrand crosslinked (ICL) structures that are potent cytotoxins. Since it is implausible that cells could possess distinct DNA repair systems for each individual ICL, it is believed that common structural and dynamic fe...

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Detalhes bibliográficos
Main Authors: Friedman, Joshua I., Jiang, Yu Lin, Miller, Paul S., Stivers, James T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3032004/
https://ncbi.nlm.nih.gov/pubmed/21174443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101813h
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