Lysine Residue 185 of Rad1 Is a Topological but Not a Functional Counterpart of Lysine Residue 164 of PCNA

Monoubiquitylation of the homotrimeric DNA sliding clamp PCNA at lysine residue 164 (PCNA(K164)) is a highly conserved, DNA damage-inducible process that is mediated by the E2/E3 complex Rad6/Rad18. This ubiquitylation event recruits translesion synthesis (TLS) polymerases capable of replicating acr...

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Autores principales: Wit, Niek, Krijger, Peter H. L., van den Berk, Paul C. M., Jacobs, Heinz
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031632/
https://ncbi.nlm.nih.gov/pubmed/21304913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016669
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