Loss of Guanylyl Cyclase C (GCC) Signaling Leads to Dysfunctional Intestinal Barrier

BACKGROUND: Guanylyl Cyclase C (GCC) signaling via uroguanylin (UGN) and guanylin activation is a critical mediator of intestinal fluid homeostasis, intestinal cell proliferation/apoptosis, and tumorigenesis. As a mechanism for some of these effects, we hypothesized that GCC signaling mediates regul...

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Autors principals: Han, Xiaonan, Mann, Elizabeth, Gilbert, Shila, Guan, Yanfang, Steinbrecher, Kris A., Montrose, Marshall H., Cohen, Mitchell B.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031533/
https://ncbi.nlm.nih.gov/pubmed/21305056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016139
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