Are Zinc-Finger Domains of Protein Kinase C Dynamic Structures That Unfold by Lipid or Redox Activation?

Protein kinase C (PKC) is activated by lipid second messengers or redox action, raising the question whether these activation modes involve the same or alternate mechanisms. Here we show that both lipid activators and oxidation target the zinc-finger domains of PKC, suggesting a unifying activation...

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Bibliografiske detaljer
Main Authors: Zhao, Feng, Ilbert, Marianne, Varadan, Ranjani, Cremers, Claudia M., Hoyos, Beatrice, Acin-Perez, Rebeca, Vinogradov, Valerie, Cowburn, David, Jakob, Ursula, Hammerling, Ulrich
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2011
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News & Views
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3030452/
https://ncbi.nlm.nih.gov/pubmed/21067413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2010.3773
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