Regulation of intermediary metabolism by the PKCδ signalosome in mitochondria

PKCδ has emerged as a novel regulatory molecule of oxidative phosphorylation by targeting the pyruvate dehydrogenase complex (PDHC). We showed that activation of PKCδ leads to the dephosphorylation of pyruvate dehydrogenase kinase 2 (PDK2), thereby decreasing PDK2 activity and increasing PDH activit...

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Detalhes bibliográficos
Main Authors: Acin-Perez, Rebeca, Hoyos, Beatrice, Gong, Jianli, Vinogradov, Valerie, Fischman, Donald A., Leitges, Michael, Borhan, Babak, Starkov, Anatoly, Manfredi, Giovanni, Hammerling, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2010
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992363/
https://ncbi.nlm.nih.gov/pubmed/20798245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-166934
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