Regulation of intermediary metabolism by the PKCδ signalosome in mitochondria

PKCδ has emerged as a novel regulatory molecule of oxidative phosphorylation by targeting the pyruvate dehydrogenase complex (PDHC). We showed that activation of PKCδ leads to the dephosphorylation of pyruvate dehydrogenase kinase 2 (PDK2), thereby decreasing PDK2 activity and increasing PDH activit...

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Main Authors: Acin-Perez, Rebeca, Hoyos, Beatrice, Gong, Jianli, Vinogradov, Valerie, Fischman, Donald A., Leitges, Michael, Borhan, Babak, Starkov, Anatoly, Manfredi, Giovanni, Hammerling, Ulrich
Format: Artigo
Jezik:Inglês
Izdano: Federation of American Societies for Experimental Biology 2010
Teme:
Research Communications
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992363/
https://ncbi.nlm.nih.gov/pubmed/20798245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-166934
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