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Telomerase Inhibitor PinX1 Provides a Link between TRF1 and Telomerase to Prevent Telomere Elongation

Telomere maintenance is essential for protecting chromosome ends. Aberrations in telomere length have been implicated in cancer and aging. Telomere elongation by human telomerase is inhibited in cis by the telomeric protein TRF1 and its associated proteins. However, the link between TRF1 and inhibit...

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Main Authors: Soohoo, Christina Y., Shi, Rong, Lee, Tae Ho, Huang, Pengyu, Lu, Kun Ping, Zhou, Xiao Zhen
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3030390/
https://ncbi.nlm.nih.gov/pubmed/21119197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.180174
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