Processing of Optineurin in Neuronal Cells

Optineurin is a gene linked to amyotrophic lateral sclerosis, Paget disease of bone, and glaucoma, a major blinding disease. Mutations such as E50K were identified in glaucoma patients. We investigated herein the involvement of ubiquitin-proteasome pathway (UPP) and autophagy, two major routes for p...

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Bibliographische Detailangaben
Hauptverfasser: Shen, Xiang, Ying, Hongyu, Qiu, Ye, Park, Jeong-Seok, Shyam, Rajalekshmy, Chi, Zai-Long, Iwata, Takeshi, Yue, Beatrice Y. J. T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3030366/
https://ncbi.nlm.nih.gov/pubmed/21059646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.175810
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