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Impairment of Protein Trafficking upon Overexpression and Mutation of Optineurin
BACKGROUND: Glaucoma is a major blinding disease characterized by progressive loss of retinal ganglion cells (RGCs) and axons. Optineurin is one of the candidate genes identified so far. A mutation of Glu(50) to Lys (E50K) has been reported to be associated with a more progressive and severe disease...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2902519/ https://ncbi.nlm.nih.gov/pubmed/20634958 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011547 |
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