Heterocomplexes of Mannose-binding Lectin and the Pentraxins PTX3 or Serum Amyloid P Component Trigger Cross-activation of the Complement System

The long pentraxin 3 (PTX3), serum amyloid P component (SAP), and C-reactive protein belong to the pentraxin family of pattern recognition molecules involved in tissue homeostasis and innate immunity. They interact with C1q from the classical complement pathway. Whether this also occurs via the anal...

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Hlavní autoři: Ma, Ying Jie, Doni, Andrea, Skjoedt, Mikkel-Ole, Honoré, Christian, Arendrup, Maiken, Mantovani, Alberto, Garred, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3030347/
https://ncbi.nlm.nih.gov/pubmed/21106539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.190637
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