A Novel Mannose-binding Lectin/Ficolin-associated Protein Is Highly Expressed in Heart and Skeletal Muscle Tissues and Inhibits Complement Activation

The human lectin complement pathway involves circulating complexes consisting of mannose-binding lectin (MBL) or three ficolins (ficolin-1, -2, and -3) in association with three MBL/ficolin-associated serine proteases (MASP) (MASP-1, -2, and -3) and a nonenzymatic sMAP. MASP-1 and MASP-3 (MASP1 isof...

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Detalhes bibliográficos
Main Authors: Skjoedt, Mikkel-Ole, Hummelshoj, Tina, Palarasah, Yaseelan, Honore, Christian, Koch, Claus, Skjodt, Karsten, Garred, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832975/
https://ncbi.nlm.nih.gov/pubmed/20053996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.065805
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