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Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB

The second messenger phosphatidylinositol (3,4,5)-trisphosphate (PIP(3)), formed by the p110 family of PI3-kinases, promotes cellular growth, proliferation, and survival, in large part by activating the protein kinase Akt/PKB. We show that inositol polyphosphate multikinase (IPMK) physiologically ge...

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Main Authors: Maag, David, Maxwell, Micah J., Hardesty, Douglas A., Boucher, Katie L., Choudhari, Namrata, Hanno, Adam G., Ma, Jenny F., Snowman, Adele S., Pietropaoli, Joseph W., Xu, Risheng, Storm, Phillip B., Saiardi, Adolfo, Snyder, Solomon H., Resnick, Adam C.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029688/
https://ncbi.nlm.nih.gov/pubmed/21220345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1017831108
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