Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB

The second messenger phosphatidylinositol (3,4,5)-trisphosphate (PIP(3)), formed by the p110 family of PI3-kinases, promotes cellular growth, proliferation, and survival, in large part by activating the protein kinase Akt/PKB. We show that inositol polyphosphate multikinase (IPMK) physiologically ge...

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Bibliografiske detaljer
Main Authors: Maag, David, Maxwell, Micah J., Hardesty, Douglas A., Boucher, Katie L., Choudhari, Namrata, Hanno, Adam G., Ma, Jenny F., Snowman, Adele S., Pietropaoli, Joseph W., Xu, Risheng, Storm, Phillip B., Saiardi, Adolfo, Snyder, Solomon H., Resnick, Adam C.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029688/
https://ncbi.nlm.nih.gov/pubmed/21220345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1017831108
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