Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB

The second messenger phosphatidylinositol (3,4,5)-trisphosphate (PIP(3)), formed by the p110 family of PI3-kinases, promotes cellular growth, proliferation, and survival, in large part by activating the protein kinase Akt/PKB. We show that inositol polyphosphate multikinase (IPMK) physiologically ge...

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Detalhes bibliográficos
Main Authors: Maag, David, Maxwell, Micah J., Hardesty, Douglas A., Boucher, Katie L., Choudhari, Namrata, Hanno, Adam G., Ma, Jenny F., Snowman, Adele S., Pietropaoli, Joseph W., Xu, Risheng, Storm, Phillip B., Saiardi, Adolfo, Snyder, Solomon H., Resnick, Adam C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029688/
https://ncbi.nlm.nih.gov/pubmed/21220345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1017831108
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