Identification of Subtilase Cytotoxin (SubAB) Receptors Whose Signaling, in Association with SubAB-Induced BiP Cleavage, Is Responsible for Apoptosis in HeLa Cells

Subtilase cytotoxin (SubAB), which is produced by certain strains of Shiga-toxigenic Escherichia coli (STEC), causes the 78-kDa glucose-regulated protein (GRP78/BiP) cleavage, followed by induction of endoplasmic reticulum (ER) stress, leading to caspase-dependent apoptosis via mitochondrial membran...

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Detalhes bibliográficos
Main Authors: Yahiro, Kinnosuke, Satoh, Mamoru, Morinaga, Naoko, Tsutsuki, Hiroyasu, Ogura, Kohei, Nagasawa, Sayaka, Nomura, Fumio, Moss, Joel, Noda, Masatoshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028836/
https://ncbi.nlm.nih.gov/pubmed/21098100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01020-10
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