Combination effects of platinum drugs and N(1), N(11) diethylnorspermine on spermidine/spermine N(1)-acetyltransferase, polyamines and growth inhibition in A2780 human ovarian carcinoma cells and their oxaliplatin and cisplatin-resistant variants

PURPOSE: To understand the mechanisms behind platinum drug/DENSPM-induced inhibition of cancer cell growth, we compared the effects of oxaliplatin and cisplatin when combined with DENSPM on the induction of SSAT mRNA, activity, polyamines and cell growth in A2780 human ovarian carcinoma cells and th...

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Bibliografische gegevens
Hoofdauteurs: Tummala, Ramakumar, Diegelman, Paula, Hector, Suzanne, Kramer, Debora L., Clark, Kimberly, Zagst, Patricia, Fetterly, Gerald, Porter, Carl W., Pendyala, Lakshmi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer-Verlag 2010
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028085/
https://ncbi.nlm.nih.gov/pubmed/20443003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-010-1334-9
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