Characterization of Pt-, Pd-spermine complexes for their effect on polyamine pathway and cisplatin resistance in A2780 ovarian carcinoma cells

We have previously showed that platinum drugs up-regulate SSAT and SMO and down-regulate ODC and SAMDC in the polyamine pathway. Several studies including our own established that platinum drugs combined with polyamine analog DENSPM produces synergistic increase in SSAT activity with polyamine deple...

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Autors principals: TUMMALA, RAMAKUMAR, DIEGELMAN, PAULA, FIUZA, SONIA M., BATISTA DE CARVALHO, LUIS A.E., MARQUES, MARIA PAULA M., KRAMER, DEBORA L., CLARK, KIMBERLY, VUJCIC, SLAVOLJUB, PORTER, CARL W., PENDYALA, LAKSHMI
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900932/
https://ncbi.nlm.nih.gov/pubmed/20514439
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