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Oligonucleotide therapeutic approaches for Huntington disease

Huntington disease is an autosomal dominant neurodegenerative disorder caused by a toxic expansion in the CAG repeat region of the huntingtin gene. Oligonucleotide approaches based on RNAi and antisense oligonucleotides provide promising new therapeutic strategies for direct intervention through red...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Sah, Dinah W.Y., Aronin, Neil
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3026739/
https://ncbi.nlm.nih.gov/pubmed/21285523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45130
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