Mutation of NIMA-related kinase 1 (NEK1) leads to chromosome instability

BACKGROUND: NEK1, the first mammalian ortholog of the fungal protein kinase never-in-mitosis A (NIMA), is involved early in the DNA damage sensing/repair pathway. A defect in DNA repair in NEK1-deficient cells is suggested by persistence of DNA double strand breaks after low dose ionizing radiation...

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Main Authors: Chen, Yumay, Chen, Chi-Fen, Chiang, Huai-Chin, Pena, Michelle, Polci, Rosaria, Wei, Randy L, Edwards, Robert A, Hansel, Donna E, Chen, Phang-Lang, Riley, Daniel J
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2011
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025975/
https://ncbi.nlm.nih.gov/pubmed/21214959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-5
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