Mutation of NIMA-related kinase 1 (NEK1) leads to chromosome instability

BACKGROUND: NEK1, the first mammalian ortholog of the fungal protein kinase never-in-mitosis A (NIMA), is involved early in the DNA damage sensing/repair pathway. A defect in DNA repair in NEK1-deficient cells is suggested by persistence of DNA double strand breaks after low dose ionizing radiation...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Chen, Yumay, Chen, Chi-Fen, Chiang, Huai-Chin, Pena, Michelle, Polci, Rosaria, Wei, Randy L, Edwards, Robert A, Hansel, Donna E, Chen, Phang-Lang, Riley, Daniel J
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2011
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025975/
https://ncbi.nlm.nih.gov/pubmed/21214959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-5
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge