Escape from HER family tyrosine kinase inhibitor therapy by the kinase inactive HER3

Oncogenic tyrosine kinases have proven to be promising targets for the development of highly effective anticancer drugs. However HER family tyrosine kinase inhibitors (TKIs) show only limited activity against HER2-driven cancers despite effective inhibition of EGFR and HER2 in vivo 1–8. The reasons...

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Bibliografiska uppgifter
Huvudupphovsmän: Sergina, Natalia V., Rausch, Megan, Wang, Donghui, Blair, Jimmy, Hann, Byron, Shokat, Kevan M., Moasser, Mark M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2007
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025857/
https://ncbi.nlm.nih.gov/pubmed/17206155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature05474
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