HER2 Oncogenic Function Escapes EGFR Tyrosine Kinase Inhibitors via Activation of Alternative HER Receptors in Breast Cancer Cells

BACKGROUND: The response rate to EGFR tyrosine kinase inhibitors (TKIs) may be poor and unpredictable in cancer patients with EGFR expression itself being an inadequate response indicator. There is limited understanding of the mechanisms underlying this resistance. Furthermore, although TKIs suppres...

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Hlavní autoři: Kong, Anthony, Calleja, Véronique, Leboucher, Pierre, Harris, Adrian, Parker, Peter J., Larijani, Banafshé
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2008
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2483931/
https://ncbi.nlm.nih.gov/pubmed/18682844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002881
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