Differential Reactivity Between Two Copper Sites in Peptidylglycine α-Hydroxylating Monooxygenase (PHM)

Peptidylglycine α-Hydroxylating Monooxygenase (PHM) catalyzes the stereospecific hydroxylation of the Cα of C-terminal glycine-extended peptides and proteins, the first step in the activation of many peptide hormones, growth factors and neurotransmitters. The crystal structure of the enzyme revealed...

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Autores principales: Chufán, Eduardo E., Prigge, Sean T., Siebert, Xavier, Eipper, Betty A., Mains, Richard E., Amzel, L. Mario
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025614/
https://ncbi.nlm.nih.gov/pubmed/20958070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja103117r
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