Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation

Histone acetyltransferases (HATs) GCN5 and PCAF (GCN5/PCAF) and CBP and p300 (CBP/p300) are transcription co-activators. However, how these two distinct families of HATs regulate gene activation remains unclear. Here, we show deletion of GCN5/PCAF in cells specifically and dramatically reduces acety...

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Hlavní autoři: Jin, Qihuang, Yu, Li-Rong, Wang, Lifeng, Zhang, Zhijing, Kasper, Lawryn H, Lee, Ji-Eun, Wang, Chaochen, Brindle, Paul K, Dent, Sharon Y R, Ge, Kai
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025463/
https://ncbi.nlm.nih.gov/pubmed/21131905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.318
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