Gcn5 and PCAF negatively regulate interferon-β production through HAT-independent inhibition of TBK1

Viral infection triggers innate immune signaling, which in turn induces interferon-β (IFN-β) production to establish innate antiviral immunity. Previous studies showed that Gcn5 (Kat2a), a histone acetyltransferase (HAT) with partial functional redundancy with PCAF (Kat2b), and Gcn5/PCAF-mediated hi...

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Bibliographic Details
Published in:EMBO Rep
Main Authors: Jin, Qihuang, Zhuang, Lenan, Lai, Binbin, Wang, Chaochen, Li, Wenqian, Dolan, Brian, Lu, Yue, Wang, Zhibin, Zhao, Keji, Peng, Weiqun, Dent, Sharon YR, Ge, Kai
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2014
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Scientific Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253493/
https://ncbi.nlm.nih.gov/pubmed/25269644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201438990
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