Crystal Structures of RNase H2 in Complex with Nucleic Acid Reveal the Mechanism of RNA-DNA Junction Recognition and Cleavage

Two classes of RNase H hydrolyze RNA of RNA/DNA hybrids. In contrast to RNase H1 that requires four ribonucleotides for cleavage, RNase H2 can nick duplex DNAs containing a single ribonucleotide, suggesting different in vivo substrates. We report here the crystal structures of a type 2 RNase H in co...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Rychlik, Monika P., Chon, Hyongi, Cerritelli, Susana M., Klimek, Paulina, Crouch, Robert J., Nowotny, Marcin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cell Press 2010
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025331/
https://ncbi.nlm.nih.gov/pubmed/21095591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.11.001
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