Identification of genetic determinants of IGF-1 levels and longevity among mouse inbred strains

The IGF-1 signaling pathway plays an important role in regulating longevity. To identify the genetic loci and genes that regulate plasma IGF-1 levels, we intercrossed MRL/MpJ and SM/J, inbred mouse strains that differ in IGF-1 levels. Quantitative trait loci (QTL) analysis of IGF-1 levels of these F...

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Auteurs principaux: Leduc, Magalie S., Hageman, Rachael S., Meng, Qingying, Verdugo, Ricardo A., Tsaih, Shirng-Wern, Churchill, Gary A., Paigen, Beverly, Yuan, Rong
Format: Artigo
Langue:Inglês
Publié: 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025299/
https://ncbi.nlm.nih.gov/pubmed/20735370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2010.00612.x
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